A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma

A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma

Introduction: Hepatocellular carcinoma (HCC) is a fatal cancer that is often diagnosed at the advanced stages which limits the available therapeutic options. The interaction of HGF with c-MET (a receptor tyrosine kinase) results in the activation of c-MET which subsequently triggers the PI3K/Akt/mTO...

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Main Authors: Shalini V. Gowda, Na Young Kim, Kachigere B. Harsha, Darshini Gowda, Rajaghatta N. Suresh, Amudha Deivasigamani, Chakrabhavi Dhananjaya Mohan, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn, Kanchugarakoppal S. Rangappa
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
c-MET
Hepatocellular carcinoma
Indirubin
Triazole
Orthotopic mice model
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003771
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