Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species
Abstract Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, is greatly limited by the hypoxia in the tumor microenvironment (TME) and the antioxidant defense. Amplification of oxidative stress has been successfully empl...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55658-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544487557398528 |
|---|---|
| author | Jinglin Zou Cong Jiang Qiangsheng Hu Xinlin Jia Shuqi Wang Shiyue Wan Yuanqing Mao Dapeng Zhang Peng Zhang Bin Dai Yongsheng Li |
| author_facet | Jinglin Zou Cong Jiang Qiangsheng Hu Xinlin Jia Shuqi Wang Shiyue Wan Yuanqing Mao Dapeng Zhang Peng Zhang Bin Dai Yongsheng Li |
| author_sort | Jinglin Zou |
| collection | DOAJ |
| description | Abstract Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, is greatly limited by the hypoxia in the tumor microenvironment (TME) and the antioxidant defense. Amplification of oxidative stress has been successfully employed for tumor therapy, but the interactions between cancer cells and the other factors of TME usually lead to inadequate tumor treatments. To tackle this issue, we develop a pH/redox dual-responsive nanomedicine based on the remodeling of cancer-associated fibroblasts (CAFs) for multi-pronged amplification of ROS (ZnPP@FQOS). It is demonstrated that ROS generated by ZnPP@FQOS is endogenously/exogenously multiply amplified owing to the CAFs remodeling and down-regulation of anti-oxidative stress in cancer cells, ultimately achieving the efficient photodynamic therapy in a female tumor-bearing mouse model. More importantly, ZnPP@FQOS is verified to enable the stimulation of enhanced immune responses and systemic immunity. This strategy remarkably potentiates the efficacy of photodynamic-immunotherapy, thus providing a promising enlightenment for tumor therapy. |
| format | Article |
| id | doaj-art-09b5c94fd5624c0b85ad7bb65ec9e65c |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-09b5c94fd5624c0b85ad7bb65ec9e65c2025-01-12T12:29:46ZengNature PortfolioNature Communications2041-17232025-01-0116111610.1038/s41467-024-55658-0Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen speciesJinglin Zou0Cong Jiang1Qiangsheng Hu2Xinlin Jia3Shuqi Wang4Shiyue Wan5Yuanqing Mao6Dapeng Zhang7Peng Zhang8Bin Dai9Yongsheng Li10Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and TechnologyDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of MedicineShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineLab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and TechnologyDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of MedicineShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineLab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and TechnologyDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of MedicineKey Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi UniversityLab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and TechnologyAbstract Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, is greatly limited by the hypoxia in the tumor microenvironment (TME) and the antioxidant defense. Amplification of oxidative stress has been successfully employed for tumor therapy, but the interactions between cancer cells and the other factors of TME usually lead to inadequate tumor treatments. To tackle this issue, we develop a pH/redox dual-responsive nanomedicine based on the remodeling of cancer-associated fibroblasts (CAFs) for multi-pronged amplification of ROS (ZnPP@FQOS). It is demonstrated that ROS generated by ZnPP@FQOS is endogenously/exogenously multiply amplified owing to the CAFs remodeling and down-regulation of anti-oxidative stress in cancer cells, ultimately achieving the efficient photodynamic therapy in a female tumor-bearing mouse model. More importantly, ZnPP@FQOS is verified to enable the stimulation of enhanced immune responses and systemic immunity. This strategy remarkably potentiates the efficacy of photodynamic-immunotherapy, thus providing a promising enlightenment for tumor therapy.https://doi.org/10.1038/s41467-024-55658-0 |
| spellingShingle | Jinglin Zou Cong Jiang Qiangsheng Hu Xinlin Jia Shuqi Wang Shiyue Wan Yuanqing Mao Dapeng Zhang Peng Zhang Bin Dai Yongsheng Li Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species Nature Communications |
| title | Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species |
| title_full | Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species |
| title_fullStr | Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species |
| title_full_unstemmed | Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species |
| title_short | Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species |
| title_sort | tumor microenvironment responsive engineered hybrid nanomedicine for photodynamic immunotherapy via multi pronged amplification of reactive oxygen species |
| url | https://doi.org/10.1038/s41467-024-55658-0 |
| work_keys_str_mv | AT jinglinzou tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT congjiang tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT qiangshenghu tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT xinlinjia tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT shuqiwang tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT shiyuewan tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT yuanqingmao tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT dapengzhang tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT pengzhang tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT bindai tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies AT yongshengli tumormicroenvironmentresponsiveengineeredhybridnanomedicineforphotodynamicimmunotherapyviamultiprongedamplificationofreactiveoxygenspecies |