Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium

Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium

Introduction: Epidemiological studies have implicated ovulation as a risk factor for ovarian high-grade serous carcinoma (HGSC) at the initiation stage. Precancerous lesions of HGSC commonly exhibit TP53 mutations attributed to DNA deamination and are frequently localized in the fallopian tube epith...

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Bibliographic Details
Main Authors: Kanchana Subramani, Hsuan-Shun Huang, Pao-Chu Chen, Dah-Ching Ding, Tang-Yuan Chu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Fallopian tube fimbria
Follicular fluid
Reactive oxygen species
TP53 mutation
Activation-induced cytidine deaminase
Mutagenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862400126X
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