A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI
A novel Polyacrylamide superparamagnetic iron oxide nanoparticle platform is described which has been synthetically prepared such that multiple crystals of iron oxide are encapsulated within a single Polyacrylamide matrix ( P oly A crylamide M agnetic [PAM] nanoparticles). This formulation provides...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2003-10-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1162/15353500200303163 |
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| _version_ | 1841564514821079040 |
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| author | Bradford A. Moffat G. Ramachandra Reddy Patrick McConville Daniel E. Hall Thomas L. Chenevert Raoul R. Kopelman Martin Philbert Ralph Weissleder Alnawaz Rehemtulla Brian D. Ross |
| author_facet | Bradford A. Moffat G. Ramachandra Reddy Patrick McConville Daniel E. Hall Thomas L. Chenevert Raoul R. Kopelman Martin Philbert Ralph Weissleder Alnawaz Rehemtulla Brian D. Ross |
| author_sort | Bradford A. Moffat |
| collection | DOAJ |
| description | A novel Polyacrylamide superparamagnetic iron oxide nanoparticle platform is described which has been synthetically prepared such that multiple crystals of iron oxide are encapsulated within a single Polyacrylamide matrix ( P oly A crylamide M agnetic [PAM] nanoparticles). This formulation provides for an extremely large T 2 and T 2 * relaxivity of between 620 and 1140 sec −1 mM −1 . Administration of PAM nanoparticles into rats bearing orthotopic 9L gliomas allowed quantitative pharmacokinetic analysis of the uptake of nanoparticles in the vasculature, brain, and glioma. Addition of polyethylene glycol of varying sizes (0.6, 2, and 10 kDa) to the surface of the PAM nanoparticles resulted in an increase in plasma half-life and affected tumor uptake and retention of the nanoparticles as quantified by changes in tissue contrast using MRI. The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications. |
| format | Article |
| id | doaj-art-091c5f57b40142e9b8e7ae86b859dd8f |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2003-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-091c5f57b40142e9b8e7ae86b859dd8f2025-01-02T22:37:33ZengSAGE PublishingMolecular Imaging1536-01212003-10-01210.1162/1535350020030316310.1162_15353500200303163A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRIBradford A. Moffat0G. Ramachandra Reddy1Patrick McConville2Daniel E. Hall3Thomas L. Chenevert4Raoul R. Kopelman5Martin Philbert6Ralph Weissleder7Alnawaz Rehemtulla8Brian D. Ross9University of MichiganMolecular Therapeutics Inc.Molecular Therapeutics Inc.University of MichiganUniversity of MichiganUniversity of MichiganUniversity of MichiganMassachusetts General HospitalUniversity of MichiganUniversity of MichiganA novel Polyacrylamide superparamagnetic iron oxide nanoparticle platform is described which has been synthetically prepared such that multiple crystals of iron oxide are encapsulated within a single Polyacrylamide matrix ( P oly A crylamide M agnetic [PAM] nanoparticles). This formulation provides for an extremely large T 2 and T 2 * relaxivity of between 620 and 1140 sec −1 mM −1 . Administration of PAM nanoparticles into rats bearing orthotopic 9L gliomas allowed quantitative pharmacokinetic analysis of the uptake of nanoparticles in the vasculature, brain, and glioma. Addition of polyethylene glycol of varying sizes (0.6, 2, and 10 kDa) to the surface of the PAM nanoparticles resulted in an increase in plasma half-life and affected tumor uptake and retention of the nanoparticles as quantified by changes in tissue contrast using MRI. The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications.https://doi.org/10.1162/15353500200303163 |
| spellingShingle | Bradford A. Moffat G. Ramachandra Reddy Patrick McConville Daniel E. Hall Thomas L. Chenevert Raoul R. Kopelman Martin Philbert Ralph Weissleder Alnawaz Rehemtulla Brian D. Ross A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI Molecular Imaging |
| title | A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI |
| title_full | A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI |
| title_fullStr | A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI |
| title_full_unstemmed | A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI |
| title_short | A Novel Polyacrylamide Magnetic Nanoparticle Contrast Agent for Molecular Imaging using MRI |
| title_sort | novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using mri |
| url | https://doi.org/10.1162/15353500200303163 |
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