Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis
BackgroundMucin family members have been reported to be widely expressed in gastric carcinoma with diverse functions. Several important mucins exert the function of tumorigenesis or progression in gastric cancer (GC). Here, we conduct this meta-analysis to evaluate the association between mucin expr...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1512971/full |
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| author | Shunda Wang Yongrun Mu Jianwei Zhang Chengfeng Wang |
| author_facet | Shunda Wang Yongrun Mu Jianwei Zhang Chengfeng Wang |
| author_sort | Shunda Wang |
| collection | DOAJ |
| description | BackgroundMucin family members have been reported to be widely expressed in gastric carcinoma with diverse functions. Several important mucins exert the function of tumorigenesis or progression in gastric cancer (GC). Here, we conduct this meta-analysis to evaluate the association between mucin expression and clinicopathological features in GC.MethodsLiterature searches were performed in PubMed, Embase, The Cochrane Library, and ISI Web of Science, and, finally, 28 studies met our criteria. Odds ratios or hazard ratios with 95% confidence intervals were calculated to evaluate the effect quantity. We analyzed the expression of MUC1, MUC2, MUC5AC, and MUC6 and their clinicopathological characteristics separately at the same time.ResultsTwenty-eight studies that contain 4,603 patients were included in our meta-analysis. MUC1 was associated with gender, Lauren classification, depth of tumor invasion, TNM, vascular invasion, lymph metastasis, and lymphatic invasion, WHO grade, as well as the 5-year survival rate. MUC2 was significantly correlated with lymphatic invasion and WHO grade. MUC5AC was highly positive in gender, depth of tumor invasion, WHO grade, TNM, lymph metastasis, and lymphatic invasion. Moreover, cases with decreased MUC5AC expression were correlated with less 5-year survival. MUC6 was only related with lymphatic invasion.ConclusionOur meta-analysis showed that MUC1 and MUC5AC had prognostic value in GC detected by immunohistochemistry. MUC1 and MUC5AC were also associated with some other significant clinicopathological parameters. Moreover, MUC2 and MUC6 also exert their influence in lymphatic invasion. However, further enlarged study awaits to verify our conclusion to deeply explore the role of mucin family members in GC. |
| format | Article |
| id | doaj-art-08a048e20eae4736a6e675aeb5f724fa |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-08a048e20eae4736a6e675aeb5f724fa2025-01-16T05:10:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15129711512971Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysisShunda WangYongrun MuJianwei ZhangChengfeng WangBackgroundMucin family members have been reported to be widely expressed in gastric carcinoma with diverse functions. Several important mucins exert the function of tumorigenesis or progression in gastric cancer (GC). Here, we conduct this meta-analysis to evaluate the association between mucin expression and clinicopathological features in GC.MethodsLiterature searches were performed in PubMed, Embase, The Cochrane Library, and ISI Web of Science, and, finally, 28 studies met our criteria. Odds ratios or hazard ratios with 95% confidence intervals were calculated to evaluate the effect quantity. We analyzed the expression of MUC1, MUC2, MUC5AC, and MUC6 and their clinicopathological characteristics separately at the same time.ResultsTwenty-eight studies that contain 4,603 patients were included in our meta-analysis. MUC1 was associated with gender, Lauren classification, depth of tumor invasion, TNM, vascular invasion, lymph metastasis, and lymphatic invasion, WHO grade, as well as the 5-year survival rate. MUC2 was significantly correlated with lymphatic invasion and WHO grade. MUC5AC was highly positive in gender, depth of tumor invasion, WHO grade, TNM, lymph metastasis, and lymphatic invasion. Moreover, cases with decreased MUC5AC expression were correlated with less 5-year survival. MUC6 was only related with lymphatic invasion.ConclusionOur meta-analysis showed that MUC1 and MUC5AC had prognostic value in GC detected by immunohistochemistry. MUC1 and MUC5AC were also associated with some other significant clinicopathological parameters. Moreover, MUC2 and MUC6 also exert their influence in lymphatic invasion. However, further enlarged study awaits to verify our conclusion to deeply explore the role of mucin family members in GC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1512971/fullMUC1MUC2MUC5ACMUC6prognosisclinicopathological characteristics |
| spellingShingle | Shunda Wang Yongrun Mu Jianwei Zhang Chengfeng Wang Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis Frontiers in Oncology MUC1 MUC2 MUC5AC MUC6 prognosis clinicopathological characteristics |
| title | Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis |
| title_full | Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis |
| title_fullStr | Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis |
| title_short | Prognostic and clinicopathological significance of mucin family members expression in gastric cancer: a meta-analysis |
| title_sort | prognostic and clinicopathological significance of mucin family members expression in gastric cancer a meta analysis |
| topic | MUC1 MUC2 MUC5AC MUC6 prognosis clinicopathological characteristics |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1512971/full |
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