Osmotic laxatives do not alter dabigatran plasma concentration in healthy volunteers – a randomized, controlled, cross-over trial

Osmotic laxatives do not alter dabigatran plasma concentration in healthy volunteers – a randomized, controlled, cross-over trial

BackgroundLaxatives are among the most commonly used pharmacological agents worldwide. Available data indicate a significant potential for clinically relevant drug-drug interactions. We hypothesized that osmotic laxatives may reduce the oral bioavailability of the direct oral anticoagulant dabigatra...

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Main Authors: Matthias Weiss-Tessbach, Al Medina Dizdarevic, Alexander Kupis, Thorsten Bischof, Christa Firbas, Peter Quehenberger, Ulla Derhaschnig, Max Frimmel, Bernd Jilma, Christian Schoergenhofer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
dabigatran
laxatives
pharmacokinetics
drug-drug interactions
bioavailability
anticoagulation therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1579014/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1579014/full

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