Hyperglycemia enhances group B Streptococcus pathogenicity by impairing TLR2 expression and chemotactic response in the human placenta

Hyperglycemia enhances group B Streptococcus pathogenicity by impairing TLR2 expression and chemotactic response in the human placenta

IntroductionElevated glucose levels during pregnancy disrupt placental structure, signaling, and cellular interactions, impairing its immune response. In mothers with gestational diabetes mellitus (GDM), Streptococcus agalactiae (Group B Streptococcus, GBS) is the second leading cause of bacterial i...

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Main Authors: Rodrigo Jiménez-Escutia, Arumi Villafuerte-Pérez, Donovan Vargas-Alcantar, Karina Martínez-Garfias, Samara Rodríguez-Flores, Pilar Velázquez-Sánchez, Amaury Fortanel-Fonseca, Rodrigo Zamora-Escudero, Marcela Islas-López, Ismael Mancilla-Herrera, Lorenza Díaz, Verónica Zaga-Clavellina, Andrea Olmos-Ortiz
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
gestational diabetes mellitus
glucose
monocytes
NK cells
MCP-1
TLR-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610381/full
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