Leader cells promote immunosuppression to drive ovarian cancer progression in vivo

Summary: Over 75% of patients with ovarian cancer present with late-stage disease, often accompanied by extensive metastasis. The metastatic cascade is driven by a sub-population of transcriptionally plastic cells known as ''leader cells'' (LCs), which play a critical role in col...

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Bibliographic Details
Main Authors: Amy L. Wilson, Laura R. Moffitt, Brittany R. Doran, Bashira Basri, Jennie Do, Thomas W. Jobling, Magdalena Plebanski, Andrew N. Stephens, Maree Bilandzic
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724013305
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