Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions
The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/7816806 |
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| _version_ | 1841524835885252608 |
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| author | Ilse Yessabel Martinez Munoz Eneida del Socorro Camarillo Romero Jose de Jesus Garduno Garcia |
| author_facet | Ilse Yessabel Martinez Munoz Eneida del Socorro Camarillo Romero Jose de Jesus Garduno Garcia |
| author_sort | Ilse Yessabel Martinez Munoz |
| collection | DOAJ |
| description | The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin has also been described as a hormone that may have a key role in glucose homeostasis. The way the association of type 2 diabetes with obesity occurs is not fully understood. In recent years, the possible pathways through which irisin could interact with other organs such as the brain or bone have been described. The present paper intends to review the new findings and possible new directions in irisin research. |
| format | Article |
| id | doaj-art-077c080cdaec4d60b0844917ccd1cfef |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-077c080cdaec4d60b0844917ccd1cfef2025-02-03T05:47:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/78168067816806Irisin a Novel Metabolic Biomarker: Present Knowledge and Future DirectionsIlse Yessabel Martinez Munoz0Eneida del Socorro Camarillo Romero1Jose de Jesus Garduno Garcia2Centro de Investigacion en Ciencias Medicas, Universidad Autonoma del Estado de México, Cuerpo Academico Salud del Universitario, MexicoCentro de Investigacion en Ciencias Medicas, Universidad Autonoma del Estado de México, Cuerpo Academico Salud del Universitario, MexicoCentro de Investigacion en Ciencias Medicas, Universidad Autonoma del Estado de México, Cuerpo Academico Salud del Universitario, MexicoThe rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin has also been described as a hormone that may have a key role in glucose homeostasis. The way the association of type 2 diabetes with obesity occurs is not fully understood. In recent years, the possible pathways through which irisin could interact with other organs such as the brain or bone have been described. The present paper intends to review the new findings and possible new directions in irisin research.http://dx.doi.org/10.1155/2018/7816806 |
| spellingShingle | Ilse Yessabel Martinez Munoz Eneida del Socorro Camarillo Romero Jose de Jesus Garduno Garcia Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions International Journal of Endocrinology |
| title | Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions |
| title_full | Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions |
| title_fullStr | Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions |
| title_full_unstemmed | Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions |
| title_short | Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions |
| title_sort | irisin a novel metabolic biomarker present knowledge and future directions |
| url | http://dx.doi.org/10.1155/2018/7816806 |
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