Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease
Valvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RV–PA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1504063/full |
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| author | Zhenni Wu Zhenni Wu Zhenni Wu Mingxing Xie Mingxing Xie Mingxing Xie Li Zhang Li Zhang Li Zhang Qing He Qing He Qing He Lang Gao Lang Gao Lang Gao Mengmeng Ji Mengmeng Ji Mengmeng Ji Yixia Lin Yixia Lin Yixia Lin Yuman Li Yuman Li Yuman Li |
| author_facet | Zhenni Wu Zhenni Wu Zhenni Wu Mingxing Xie Mingxing Xie Mingxing Xie Li Zhang Li Zhang Li Zhang Qing He Qing He Qing He Lang Gao Lang Gao Lang Gao Mengmeng Ji Mengmeng Ji Mengmeng Ji Yixia Lin Yixia Lin Yixia Lin Yuman Li Yuman Li Yuman Li |
| author_sort | Zhenni Wu |
| collection | DOAJ |
| description | Valvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RV–PA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the right ventricle cannot adapt to the elevated afterload by increasing its contractile function, RV-PA uncoupling occurs. RV-PA uncoupling has been shown to be associated with poor outcomes in VHD. This review summarizes the prognostic significance of RV-PA coupling in patients with VHD. |
| format | Article |
| id | doaj-art-076badc2b9774efea7037133c8f95ab1 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-076badc2b9774efea7037133c8f95ab12025-01-14T06:10:24ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.15040631504063Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart diseaseZhenni Wu0Zhenni Wu1Zhenni Wu2Mingxing Xie3Mingxing Xie4Mingxing Xie5Li Zhang6Li Zhang7Li Zhang8Qing He9Qing He10Qing He11Lang Gao12Lang Gao13Lang Gao14Mengmeng Ji15Mengmeng Ji16Mengmeng Ji17Yixia Lin18Yixia Lin19Yixia Lin20Yuman Li21Yuman Li22Yuman Li23Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaValvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RV–PA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the right ventricle cannot adapt to the elevated afterload by increasing its contractile function, RV-PA uncoupling occurs. RV-PA uncoupling has been shown to be associated with poor outcomes in VHD. This review summarizes the prognostic significance of RV-PA coupling in patients with VHD.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1504063/fullright ventricular-pulmonary artery couplingvalvular heart diseasepulmonary hypertensioncongenital heart defectright ventricular functionclinical utility |
| spellingShingle | Zhenni Wu Zhenni Wu Zhenni Wu Mingxing Xie Mingxing Xie Mingxing Xie Li Zhang Li Zhang Li Zhang Qing He Qing He Qing He Lang Gao Lang Gao Lang Gao Mengmeng Ji Mengmeng Ji Mengmeng Ji Yixia Lin Yixia Lin Yixia Lin Yuman Li Yuman Li Yuman Li Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease Frontiers in Cardiovascular Medicine right ventricular-pulmonary artery coupling valvular heart disease pulmonary hypertension congenital heart defect right ventricular function clinical utility |
| title | Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease |
| title_full | Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease |
| title_fullStr | Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease |
| title_full_unstemmed | Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease |
| title_short | Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease |
| title_sort | prognostic implication of right ventricular pulmonary artery coupling in valvular heart disease |
| topic | right ventricular-pulmonary artery coupling valvular heart disease pulmonary hypertension congenital heart defect right ventricular function clinical utility |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1504063/full |
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