mRNA vaccines in the context of cancer treatment: from concept to application
Abstract Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeutic management of malignant diseases,...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-06033-6 |
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| _version_ | 1841544334106689536 |
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| author | Qiang Fu Xiaoming Zhao Jinxia Hu Yang Jiao Yunfei Yan Xuchen Pan Xin Wang Fei Jiao |
| author_facet | Qiang Fu Xiaoming Zhao Jinxia Hu Yang Jiao Yunfei Yan Xuchen Pan Xin Wang Fei Jiao |
| author_sort | Qiang Fu |
| collection | DOAJ |
| description | Abstract Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeutic management of malignant diseases, primarily due to their impressive impact on the COVID-19 pandemic. In this comprehensive review, we offer a systematic overview of mRNA vaccines, focusing on the optimization of structural design, the crucial role of delivery materials, and the administration route. Additionally, we summarize preclinical studies and clinical trials to provide valuable insights into the current status of mRNA vaccines in cancer treatment. Furthermore, we delve into a systematic discussion on the significant challenges facing the current development of mRNA tumor vaccines. These challenges encompass both intrinsic and external factors that are closely intertwined with the successful application of this innovative approach. To pave the way for a more promising future in cancer treatments, a deeper understanding of immunological mechanisms, an increasing number of high-quality clinical trials, and a well-established manufacturing platform are crucial. Collaborative efforts between scientists, clinicians, and industry engineers are essential to achieving these goals. |
| format | Article |
| id | doaj-art-0751127b0d4741768762203063add001 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-0751127b0d4741768762203063add0012025-01-12T12:37:44ZengBMCJournal of Translational Medicine1479-58762025-01-0123113010.1186/s12967-024-06033-6mRNA vaccines in the context of cancer treatment: from concept to applicationQiang Fu0Xiaoming Zhao1Jinxia Hu2Yang Jiao3Yunfei Yan4Xuchen Pan5Xin Wang6Fei Jiao7School of Pharmacology, Institute of Aging Medicine, Binzhou Medical UniversityCenter of Physical Examination, Binzhou Medical University Affiliated 970 Hospital of the PLA Joint Logistic Support ForceDepartment of Biochemistry and Molecular Biology, Binzhou Medical UniversityDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic UniversityDepartment of Biochemistry and Molecular Biology, Binzhou Medical UniversityDepartment of Clinical Laboratory & Health Service Training, Binzhou Medical University Affiliated 970 Hospital of the PLA Joint Logistic Support ForceDepartment of Clinical Laboratory & Health Service Training, Binzhou Medical University Affiliated 970 Hospital of the PLA Joint Logistic Support ForceDepartment of Biochemistry and Molecular Biology, Binzhou Medical UniversityAbstract Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeutic management of malignant diseases, primarily due to their impressive impact on the COVID-19 pandemic. In this comprehensive review, we offer a systematic overview of mRNA vaccines, focusing on the optimization of structural design, the crucial role of delivery materials, and the administration route. Additionally, we summarize preclinical studies and clinical trials to provide valuable insights into the current status of mRNA vaccines in cancer treatment. Furthermore, we delve into a systematic discussion on the significant challenges facing the current development of mRNA tumor vaccines. These challenges encompass both intrinsic and external factors that are closely intertwined with the successful application of this innovative approach. To pave the way for a more promising future in cancer treatments, a deeper understanding of immunological mechanisms, an increasing number of high-quality clinical trials, and a well-established manufacturing platform are crucial. Collaborative efforts between scientists, clinicians, and industry engineers are essential to achieving these goals.https://doi.org/10.1186/s12967-024-06033-6Cancer vaccinemRNATumor-associated antigenNeoantigenLipid nanoparticleImmunotherapy |
| spellingShingle | Qiang Fu Xiaoming Zhao Jinxia Hu Yang Jiao Yunfei Yan Xuchen Pan Xin Wang Fei Jiao mRNA vaccines in the context of cancer treatment: from concept to application Journal of Translational Medicine Cancer vaccine mRNA Tumor-associated antigen Neoantigen Lipid nanoparticle Immunotherapy |
| title | mRNA vaccines in the context of cancer treatment: from concept to application |
| title_full | mRNA vaccines in the context of cancer treatment: from concept to application |
| title_fullStr | mRNA vaccines in the context of cancer treatment: from concept to application |
| title_full_unstemmed | mRNA vaccines in the context of cancer treatment: from concept to application |
| title_short | mRNA vaccines in the context of cancer treatment: from concept to application |
| title_sort | mrna vaccines in the context of cancer treatment from concept to application |
| topic | Cancer vaccine mRNA Tumor-associated antigen Neoantigen Lipid nanoparticle Immunotherapy |
| url | https://doi.org/10.1186/s12967-024-06033-6 |
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