Tumor-Colonizing <i>E. coli</i> Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models

Tumor-Colonizing <i>E. coli</i> Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models

Desmoplasia is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance. Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need. In this study, we have engineered a tumor-colonizing <i>E....

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Bibliographic Details
Main Authors: Lara C. Avsharian, Suvithanandhini Loganathan, Nancy D. Ebelt, Azadeh F. Shalamzari, Itzel Rodarte Muñoz, Edwin R. Manuel
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
pancreatic ductal adenocarcinoma
fibrosis
desmoplasia
resistance
hyaluronan
collagen
Online Access:https://www.mdpi.com/2218-273X/14/11/1458
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