Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function

Exclusion of PD-1 from the immune synapse: A novel strategy to modulate T cell function

Targeting immune checkpoint receptors on T cells is a common cancer treatment strategy. Frequently, this is accomplished through antibodies targeting the ligand of inhibitory co-receptors. Blocking the immune checkpoint PD-1 binding to its ligands PD-L1 and PD-L2 prevents downstream signaling and en...

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Bibliographic Details
Main Authors: Luke Yi Hao, Shalom Lerrer, Matthieu Paiola, Emily K. Moore, Yevgeniya Gartshteyn, Ruijiang Song, Michael Goeckeritz, Matilda J. Black, Shoiab Bukhari, Xizi Hu, Adam Mor
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
immune synapse
t cells
monoclonal antibodies
cancer immunotherapy
immune checkpoints
Online Access:http://www.sciencedirect.com/science/article/pii/S295032992400081X
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