Intrauterine administration of peripheral blood mononuclear cells helps manage recurrent implantation failure by normalizing dysregulated gene expression including estrogen-responsive genes in mice

Intrauterine administration of peripheral blood mononuclear cells helps manage recurrent implantation failure by normalizing dysregulated gene expression including estrogen-responsive genes in mice

Abstract Background Intrauterine peripheral blood mononuclear cell (PBMC) therapy for recurrent implantation failure (RIF) has been reported to improve embryo implantation by acting on the endometrium. However, the exact mode of action of PBMC on the endometrium of patients with RIF remains unclear....

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Main Authors: Yoshimi Kitawaki, Akihito Horie, Asami Ikeda, Shimpei Shitanaka, Akihiro Yanai, Tsutomu Ohara, Baku Nakakita, Yusuke Sagae, Asuka Okunomiya, Hirohiko Tani, Masaki Mandai
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Peripheral blood mononuclear cell
Intrauterine PBMC therapy
Recurrent implantation failure
Human chorionic gonadotropin
Embryo implantation
RNA-sequencing
Online Access:https://doi.org/10.1186/s12964-024-01904-3
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https://doi.org/10.1186/s12964-024-01904-3

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