Hypoxia preconditioned MSC exosomes attenuate high-altitude cerebral edema via the miR-125a-5p/RTEF-1 axis to protect vascular endothelial cells

Hypoxia preconditioned MSC exosomes attenuate high-altitude cerebral edema via the miR-125a-5p/RTEF-1 axis to protect vascular endothelial cells

Vasogenic edema, caused by the disruption of the blood-brain barrier (BBB), is a significant pathological factor in high-altitude cerebral edema (HACE). Due to the rapid progression and high mortality rate of HACE, prophylactic treatment is important. Mesenchymal stem cell exosomes (MSC-EXO) are inc...

Full description

Saved in:
Bibliographic Details
Main Authors: Jia-Chen Zuo, Jun Liang, Nan Hu, Bin Yao, Qi-Jian Zhang, Xiao-Li Zeng, Ling-Jie Zhang, Xu Zhang, Zhe-Han Chang, Chong Chen, Xin-Jian Yan, Wen-Wei Shao, Ping Zhu, Xiao-Hong Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-10-01
Series:Bioactive Materials
Subjects:
High-altitude cerebral edema
Vascular endothelial cells
Hypoxia preconditioned exosomes
miR-125a-5p
Neurological recovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002464
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X25002464

Similar Items