Aloe-emodin plus TIENAM ameliorate cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating microbiota

Aloe-emodin plus TIENAM ameliorate cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating microbiota

Despite the high sepsis-associated mortality, effective and specific treatments remain limited. Using conventional antibiotics as TIENAM (imipenem and cilastatin sodium for injection, TIE) is challenging due to increasing bacterial resistance, diminishing their efficacy and leading to adverse effect...

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Bibliographic Details
Main Authors: Jingqian Su, Xiaohui Deng, Shan Hu, Xinrui Lin, Lian Xie, Hui Ye, Congfan Lin, Fen Zhou, Shun Wu, Liling Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Microbiology
Subjects:
aloe-emodin
TIENAM
sepsis
anti-inflammatory
combination therapy
peritoneal cavity microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1491169/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1491169/full

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