Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.

Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.

This study identifies metabolic and protein phenotypic alterations in gastrocnemius, tibialis anterior and diaphragm muscles of Col6a1(-/-) mice, a model of human collagen VI myopathies. All three muscles of Col6a1(-/-) mice show some common changes in proteins involved in metabolism, resulting in d...

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Main Authors: Sara De Palma, Roberta Leone, Paolo Grumati, Michele Vasso, Roman Polishchuk, Daniele Capitanio, Paola Braghetta, Paolo Bernardi, Paolo Bonaldo, Cecilia Gelfi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0056716
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https://doi.org/10.1371/journal.pone.0056716

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