Screening and Identification of Hypoxia-Inducible Factor Signaling Inhibitor with Antiangiogenic Activity

Screening and Identification of Hypoxia-Inducible Factor Signaling Inhibitor with Antiangiogenic Activity

Hypoxia-inducible factors (HIFs) play a key role in regulating cellular responses to low-oxygen conditions, particularly in promoting angiogenesis in tumor microenvironments. Aberrant HIF signaling enhances tumor growth and contributes to resistance against chemotherapy and radiotherapy. Targeting t...

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Bibliographic Details
Main Authors: Chao Li, Yuanzheng Wei, Ping Wang, Xiaoxian Xue, Guangyao Wei, Mu Chen, Xinyun Zhang, Lei Cai, Yu Zhang, Xumu Zhang, Yingjun Li
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2024-12-01
Series:Pharmaceutical Fronts
Subjects:
hypoxia-inducible factor
HIF pathway inhibitor
angiogenesis
zebrafish
bridged compound
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1796627
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1796627

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