Study of caspase-6 activity in aggressive HCT116 cells using methotrexate-encapsulated lactoferrin-conjugated solid lipid nanoparticles via in silico and in vitro approaches

Study of caspase-6 activity in aggressive HCT116 cells using methotrexate-encapsulated lactoferrin-conjugated solid lipid nanoparticles via in silico and in vitro approaches

Abstract Methotrexate-encapsulated solid lipid nanoparticles (MTX-SLNs) and lactoferrin-decorated MTX-loaded nanoparticles (MTX-Lf-SLNs) present a promising strategy for treating colorectal cancer. Among different molecular targets, MTX demonstrated the highest affinity for Caspase-6, exhibiting a d...

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Bibliographic Details
Main Authors: Sankha Bhattacharya, Ranajit Nivrutti Shinde, Vishal Beldar, Rehan Khan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Caspase-6
Methotrexate
Lactoferrin
Molecular docking
HCT116
Online Access:https://doi.org/10.1038/s41598-025-08089-w
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https://doi.org/10.1038/s41598-025-08089-w

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