Tolerance mechanisms in polysaccharide biosynthesis: Implications for undecaprenol phosphate recycling in Escherichia coli and Shigella flexneri.

Bacterial polysaccharide synthesis is catalysed on the universal lipid carrier, undecaprenol phosphate (UndP). The cellular UndP pool is shared by different polysaccharide synthesis pathways including peptidoglycan biogenesis. Disruptions in cytosolic polysaccharide synthesis steps are detrimental t...

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Bibliographic Details
Main Authors: Jilong Qin, Yaoqin Hong, Nicholas T Maczuga, Renato Morona, Makrina Totsika
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011591
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