3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis

3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis

Abstract Background Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for clinical application in several diseases, mostly due to the paracrine activity of their secretome, exerting pro-angiogenic, antinflammatory and immunosuppressive effects. Recently, 3D culturing...

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Main Authors: G. Gerini, E. Mari, P. Pontecorvi, S. Camero, E. Romano, D. Ranieri, F. Megiorni, P. Fioramonti, A. Angeloni, C. Marchese, S. Ceccarelli
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Adipose-derived stem cells (ASCs)
Secretome
3D spheroids
Angiogenesis
microRNAs
Online Access:https://doi.org/10.1186/s13287-025-04277-7
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https://doi.org/10.1186/s13287-025-04277-7

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