Orthotopic pituitary tumors generated by stereotaxic GC cell injection in immunocompetent rats

Orthotopic pituitary tumors generated by stereotaxic GC cell injection in immunocompetent rats

Abstract Innovative treatment strategies for pituitary tumors are necessary to limit the disease burden and to improve survival in cases of carcinomas. The paucity and inaccuracy of available preclinical models substantially hamper pituitary research and drug discovery. Hence, we describe a novel me...

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Main Authors: Etienne Lefevre, Fanny Chasseloup, Nataly Ladurelle, Clément Janot, Jean Laurent Thibaud, Isabelle Beau, Clovis Adam, Céline des Courtils, Philippe Zizzari, Alexandre Carpentier, Peter Kamenický
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Preclinical model
Pituitary research
Pituitary adenoma
Tumor microenvironment
Immunocompetent rat
Online Access:https://doi.org/10.1186/s40478-025-02052-6
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https://doi.org/10.1186/s40478-025-02052-6

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