Oncogenic Ras mutant causes the hyperactivation of NF‐κB via acceleration of its transcriptional activation

Oncogenic Ras mutant causes the hyperactivation of NF‐κB via acceleration of its transcriptional activation

It is well established that nuclear factor κB (NF‐κB) acts as one of the most important transcription factors for tumor initiation and progression, as it both protects cells from apoptotic/necrotic signals and accelerates angiogenesis and tumor metastasis, which is mediated via the expression of tar...

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Main Authors: Kenji Tago, Megumi Funakoshi‐Tago, Satoshi Ohta, Hirotoshi Kawata, Hiroshi Saitoh, Hisanaga Horie, Chihiro Aoki‐Ohmura, Junji Yamauchi, Akira Tanaka, Jitsuhiro Matsugi, Ken Yanagisawa
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Molecular Oncology
Subjects:
colorectal cancer
MSK1/2
NF‐κB
p65/RelA
Ras
Online Access:https://doi.org/10.1002/1878-0261.12580
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https://doi.org/10.1002/1878-0261.12580

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