Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis
Abstract Background Wrist synovitis often leads to persistent pain, swelling, and limited mobility, causing significant functional impairment and psychological distress, including anxiety. Although arthroscopic synovectomy can alleviate physical symptoms, whether it also improves anxiety and the cau...
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BMC
2025-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-024-05432-1 |
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| author | Xunhao Wang Linyi Zhu Jingyi Mi Fei Xiong |
| author_facet | Xunhao Wang Linyi Zhu Jingyi Mi Fei Xiong |
| author_sort | Xunhao Wang |
| collection | DOAJ |
| description | Abstract Background Wrist synovitis often leads to persistent pain, swelling, and limited mobility, causing significant functional impairment and psychological distress, including anxiety. Although arthroscopic synovectomy can alleviate physical symptoms, whether it also improves anxiety and the causal relationship between synovitis and anxiety remains unclear. Methods A prospective study was conducted on 44 patients diagnosed with wrist synovitis who underwent arthroscopic synovectomy. Patients were assessed preoperatively and at 2 and 4 weeks postoperatively using the Visual Analog Scale (VAS), Mayo Wrist Score, and Self-Rating Anxiety Scale (SAS). MR analysis was employed to investigate the causal relationship between wrist synovitis and anxiety using genome-wide association studies (GWAS) summary data. Results Significant reductions in SAS and VAS scores were observed at 2 and 4 weeks postoperatively, along with improvements in wrist function as measured by the Mayo Wrist Score. MR analysis did not find statistically significant evidence of a direct causal relationship between wrist synovitis and anxiety, though a positive trend suggests that wrist synovitis may be a risk factor for anxiety. Conclusions Arthroscopic synovectomy may alleviate anxiety symptoms and may improve wrist function in patients with wrist synovitis. While a direct causal link between wrist synovitis and anxiety was not conclusively established, the observed associations highlight the need for integrated management of physical and psychological health in these patients. Trial registration This study was retrospectively registered with the WuXi 9th People’s Hospital (WuXi Orthopaedics Hospital) Medical Ethical Committee on August 6, 2023, with reference number KS2023081. |
| format | Article |
| id | doaj-art-05684b354f874ad1a61e9e5e3d7fcb87 |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-05684b354f874ad1a61e9e5e3d7fcb872025-01-05T12:41:27ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-01-0120111410.1186/s13018-024-05432-1Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysisXunhao Wang0Linyi Zhu1Jingyi Mi2Fei Xiong3Department of Sports Medicine, Wuxi 9th People’s Hospital Affiliated to Soochow UniversityDepartment of Sports Medicine, Wuxi 9th People’s Hospital Affiliated to Soochow UniversityDepartment of Sports Medicine, Wuxi 9th People’s Hospital Affiliated to Soochow UniversityDepartment of Sports Medicine, Wuxi 9th People’s Hospital Affiliated to Soochow UniversityAbstract Background Wrist synovitis often leads to persistent pain, swelling, and limited mobility, causing significant functional impairment and psychological distress, including anxiety. Although arthroscopic synovectomy can alleviate physical symptoms, whether it also improves anxiety and the causal relationship between synovitis and anxiety remains unclear. Methods A prospective study was conducted on 44 patients diagnosed with wrist synovitis who underwent arthroscopic synovectomy. Patients were assessed preoperatively and at 2 and 4 weeks postoperatively using the Visual Analog Scale (VAS), Mayo Wrist Score, and Self-Rating Anxiety Scale (SAS). MR analysis was employed to investigate the causal relationship between wrist synovitis and anxiety using genome-wide association studies (GWAS) summary data. Results Significant reductions in SAS and VAS scores were observed at 2 and 4 weeks postoperatively, along with improvements in wrist function as measured by the Mayo Wrist Score. MR analysis did not find statistically significant evidence of a direct causal relationship between wrist synovitis and anxiety, though a positive trend suggests that wrist synovitis may be a risk factor for anxiety. Conclusions Arthroscopic synovectomy may alleviate anxiety symptoms and may improve wrist function in patients with wrist synovitis. While a direct causal link between wrist synovitis and anxiety was not conclusively established, the observed associations highlight the need for integrated management of physical and psychological health in these patients. Trial registration This study was retrospectively registered with the WuXi 9th People’s Hospital (WuXi Orthopaedics Hospital) Medical Ethical Committee on August 6, 2023, with reference number KS2023081.https://doi.org/10.1186/s13018-024-05432-1Wrist synovitisAnxiety disordersArthroscopic synovectomyMendelian randomizationPhysical and mental health interplay |
| spellingShingle | Xunhao Wang Linyi Zhu Jingyi Mi Fei Xiong Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis Journal of Orthopaedic Surgery and Research Wrist synovitis Anxiety disorders Arthroscopic synovectomy Mendelian randomization Physical and mental health interplay |
| title | Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis |
| title_full | Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis |
| title_fullStr | Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis |
| title_full_unstemmed | Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis |
| title_short | Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis |
| title_sort | assessing the relationship between wrist synovitis and anxiety a study using clinical statistics and mendelian randomization analysis |
| topic | Wrist synovitis Anxiety disorders Arthroscopic synovectomy Mendelian randomization Physical and mental health interplay |
| url | https://doi.org/10.1186/s13018-024-05432-1 |
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