The Role of Autophagy in Erectile Dysfunction
Autophagy is a conservative lysosome-dependent material catabolic pathway, and exists in all eukaryotic cells. Autophagy controls cell quality and survival by eliminating intracellular dysfunction substances, and plays an important role in various pathophysiology processes. Erectile dysfunction (E...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2025-01-01
|
| Series: | The World Journal of Men's Health |
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841561232967991296 |
|---|---|
| author | Changjing Wu Yang Xiong Fudong Fu Fuxun Zhang Feng Qin Jiuhong Yuan |
| author_facet | Changjing Wu Yang Xiong Fudong Fu Fuxun Zhang Feng Qin Jiuhong Yuan |
| author_sort | Changjing Wu |
| collection | DOAJ |
| description | Autophagy is a conservative lysosome-dependent material catabolic pathway, and exists in all eukaryotic cells. Autophagy
controls cell quality and survival by eliminating intracellular dysfunction substances, and plays an important role in various
pathophysiology processes. Erectile dysfunction (ED) is a common male disease. It is resulted from a variety of causes and
pathologies, such as diabetes, hypertension, hyperlipidemia, aging, spinal cord injury, or cavernous nerve injury caused by
radical prostatectomy, and others. In the past decade, autophagy has begun to be investigated in ED. Subsequently, an increasing
number of studies have revealed the regulation of autophagy contributes to the recovery of ED, and which is mainly
involved in improving endothelial function, smooth muscle cell apoptosis, penile fibrosis, and corpus cavernosum nerve injury.
Therefore, in this review, we aim to summarize the possible role of autophagy in ED from a cellular perspective, and we
look forward to providing a new idea for the pathogenesis investigation and clinical treatment of ED in the future. |
| format | Article |
| id | doaj-art-054bdf4184f34ac9a5ecf5358334ffc0 |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-054bdf4184f34ac9a5ecf5358334ffc02025-01-03T02:45:23ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-01-01431284010.5534/wjmh.230145The Role of Autophagy in Erectile DysfunctionChangjing Wu0https://orcid.org/0000-0002-8684-1825Yang Xiong1https://orcid.org/0000-0003-3901-2394Fudong Fu2https://orcid.org/0000-0001-8773-694XFuxun Zhang3https://orcid.org/0000-0003-0113-0395Feng Qin4https://orcid.org/0000-0001-9521-7146Jiuhong Yuan5https://orcid.org/0000-0002-0991-1463West China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaAutophagy is a conservative lysosome-dependent material catabolic pathway, and exists in all eukaryotic cells. Autophagy controls cell quality and survival by eliminating intracellular dysfunction substances, and plays an important role in various pathophysiology processes. Erectile dysfunction (ED) is a common male disease. It is resulted from a variety of causes and pathologies, such as diabetes, hypertension, hyperlipidemia, aging, spinal cord injury, or cavernous nerve injury caused by radical prostatectomy, and others. In the past decade, autophagy has begun to be investigated in ED. Subsequently, an increasing number of studies have revealed the regulation of autophagy contributes to the recovery of ED, and which is mainly involved in improving endothelial function, smooth muscle cell apoptosis, penile fibrosis, and corpus cavernosum nerve injury. Therefore, in this review, we aim to summarize the possible role of autophagy in ED from a cellular perspective, and we look forward to providing a new idea for the pathogenesis investigation and clinical treatment of ED in the future.apoptosisautophagyendothelial cellserectile dysfunctionfibrosissmooth muscle |
| spellingShingle | Changjing Wu Yang Xiong Fudong Fu Fuxun Zhang Feng Qin Jiuhong Yuan The Role of Autophagy in Erectile Dysfunction The World Journal of Men's Health apoptosis autophagy endothelial cells erectile dysfunction fibrosis smooth muscle |
| title | The Role of Autophagy in Erectile Dysfunction |
| title_full | The Role of Autophagy in Erectile Dysfunction |
| title_fullStr | The Role of Autophagy in Erectile Dysfunction |
| title_full_unstemmed | The Role of Autophagy in Erectile Dysfunction |
| title_short | The Role of Autophagy in Erectile Dysfunction |
| title_sort | role of autophagy in erectile dysfunction |
| topic | apoptosis autophagy endothelial cells erectile dysfunction fibrosis smooth muscle |
| work_keys_str_mv | AT changjingwu theroleofautophagyinerectiledysfunction AT yangxiong theroleofautophagyinerectiledysfunction AT fudongfu theroleofautophagyinerectiledysfunction AT fuxunzhang theroleofautophagyinerectiledysfunction AT fengqin theroleofautophagyinerectiledysfunction AT jiuhongyuan theroleofautophagyinerectiledysfunction AT changjingwu roleofautophagyinerectiledysfunction AT yangxiong roleofautophagyinerectiledysfunction AT fudongfu roleofautophagyinerectiledysfunction AT fuxunzhang roleofautophagyinerectiledysfunction AT fengqin roleofautophagyinerectiledysfunction AT jiuhongyuan roleofautophagyinerectiledysfunction |