Three-dimensional organotypic mouse brain slices to study Alzheimer’s disease pathologies: a review

Three-dimensional organotypic mouse brain slices to study Alzheimer’s disease pathologies: a review

Alzheimer’s disease (AD) is a severe neurodegenerative brain disorder molecularly characterized by extracellular β-amyloid plaques, intraneuronal tau neurofibrillary tangles, cholinergic neuron death, neuroinflammation, vascular damage, and astroglial and microglial activation. AD is a complex disor...

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Bibliographic Details
Main Author:	Christian Humpel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Dementia
Subjects:	Alzheimer’s disease organotypic 3D culture brain slice pathology review
Online Access:	https://www.frontiersin.org/articles/10.3389/frdem.2025.1585124/full
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