Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study
Mental disorders seriously affect people’s health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were...
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Tsinghua University Press
2024-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250156 |
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| author | Yuanyuan Wang Lirong Dong Meng Zhao Shiyu Yin Pan Da Dengfeng Xu Yifei Lu Jiayue Xia Niannian Wang Shaokang Wang Guiju Sun |
| author_facet | Yuanyuan Wang Lirong Dong Meng Zhao Shiyu Yin Pan Da Dengfeng Xu Yifei Lu Jiayue Xia Niannian Wang Shaokang Wang Guiju Sun |
| author_sort | Yuanyuan Wang |
| collection | DOAJ |
| description | Mental disorders seriously affect people’s health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW:OR = 1.139, 95% CI: 1.023-1.269, P = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (P > 0.05). In the reverse MR analysis, individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC (P = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (P = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (P > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality. |
| format | Article |
| id | doaj-art-0544c77d4e2f485a8eb0dd0686d64cc8 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-0544c77d4e2f485a8eb0dd0686d64cc82025-01-10T06:56:47ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-07-011341877188510.26599/FSHW.2022.9250156Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization studyYuanyuan Wang0Lirong Dong1Meng Zhao2Shiyu Yin3Pan Da4Dengfeng Xu5Yifei Lu6Jiayue Xia7Niannian Wang8Shaokang Wang9Guiju Sun10Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaDepartment of Integrated Service and Management, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaMental disorders seriously affect people’s health and social stability. This Mendelian randomization (MR) study was designed to investigate the causal relationship between circulating vitamin C (VC) or 25-hydroxyvitamin D (25(OH)D) levels and mental disorders. The data used for the MR analysis were derived from the summary genome-wide association studies (GWAS) database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders. Based on the inverse variance weighted (IVW) method, we found a potential causal association between circulating VC and anxiety disorders (IVW:OR = 1.139, 95% CI: 1.023-1.269, P = 0.018). However, no causal association was found between VC or 25(OH)D and other mental disorders (P > 0.05). In the reverse MR analysis, individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC (P = 0.012), while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D (P = 0.012). However, the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders. In addition, there was no causal association between circulating VC and 25(OH)D (P > 0.05). Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.https://www.sciopen.com/article/10.26599/FSHW.2022.9250156circulating vitamin c25-hydroxyvitamin dmental disordermendelian randomization |
| spellingShingle | Yuanyuan Wang Lirong Dong Meng Zhao Shiyu Yin Pan Da Dengfeng Xu Yifei Lu Jiayue Xia Niannian Wang Shaokang Wang Guiju Sun Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study Food Science and Human Wellness circulating vitamin c 25-hydroxyvitamin d mental disorder mendelian randomization |
| title | Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study |
| title_full | Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study |
| title_fullStr | Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study |
| title_full_unstemmed | Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study |
| title_short | Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders - a Mendelian randomization study |
| title_sort | causal relationship between circulating vitamin c and 25 hydroxyvitamin d concentrations and common mental disorders a mendelian randomization study |
| topic | circulating vitamin c 25-hydroxyvitamin d mental disorder mendelian randomization |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250156 |
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