Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder
Abstract Background The high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD), has led to the study of their shared and disorder-specific neural substrates. However, the morphometric similarity network (MSN...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12888-024-06460-1 |
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| author | Guifeng Tan Minlan Yuan Lun Li Hongru Zhu Su Lui Changjian Qiu Wei Zhang |
| author_facet | Guifeng Tan Minlan Yuan Lun Li Hongru Zhu Su Lui Changjian Qiu Wei Zhang |
| author_sort | Guifeng Tan |
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| description | Abstract Background The high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD), has led to the study of their shared and disorder-specific neural substrates. However, the morphometric similarity network (MSN) differences among these disorders remain unknown. Methods MSN derived from T1-weighted images in patients of GAD, PTSD, and SAD, and health controls (HC) using a Siemens 3T magnetic resonance imaging system. Covariance analysis and post hoc tests were used to investigate group differences. In addition, the relationship between MSN and clinical characteristics was analyzed. Results Increased morphometric similarity (MS) between left bankssts (BA22, superior temporal cortex, STC) and right precentral gyrus, and decreased MS between left precentral gyrus and right cuneus_part1/part2, and between right rostral middle frontal cortex (rMFC) and right STC were common in GAD and PTSD relative to HC and SAD. Compared to the other three groups, SAD exhibited disorder-specific alterations of increased MS between right rMFC and right STC, and between left cuneus and right inferior parietal cortex. Additionally, increased regional MSN in left precentral gyrus was found in PTSD compared to HC and SAD. A mild positive correlation of the MS value between left bankssts and right precentral gyrus and the Hamilton Anxiety Rating Scale scores (uncorrected p = 0.041) was found in PTSD. Conclusions Our study provides the first evidence for common and distinct brain MSN abnormalities underlying the pathophysiology of GAD, PTSD, and SAD, which may aid in differential diagnosis and determining potential disorder-specific intervention targets. |
| format | Article |
| id | doaj-art-05207a7c46214556befec9c77c17e6b4 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-05207a7c46214556befec9c77c17e6b42025-01-05T12:42:45ZengBMCBMC Psychiatry1471-244X2025-01-0125111010.1186/s12888-024-06460-1Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorderGuifeng Tan0Minlan Yuan1Lun Li2Hongru Zhu3Su Lui4Changjian Qiu5Wei Zhang6Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan UniversityMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan UniversityMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan UniversityMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan UniversityMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan UniversityAbstract Background The high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD), has led to the study of their shared and disorder-specific neural substrates. However, the morphometric similarity network (MSN) differences among these disorders remain unknown. Methods MSN derived from T1-weighted images in patients of GAD, PTSD, and SAD, and health controls (HC) using a Siemens 3T magnetic resonance imaging system. Covariance analysis and post hoc tests were used to investigate group differences. In addition, the relationship between MSN and clinical characteristics was analyzed. Results Increased morphometric similarity (MS) between left bankssts (BA22, superior temporal cortex, STC) and right precentral gyrus, and decreased MS between left precentral gyrus and right cuneus_part1/part2, and between right rostral middle frontal cortex (rMFC) and right STC were common in GAD and PTSD relative to HC and SAD. Compared to the other three groups, SAD exhibited disorder-specific alterations of increased MS between right rMFC and right STC, and between left cuneus and right inferior parietal cortex. Additionally, increased regional MSN in left precentral gyrus was found in PTSD compared to HC and SAD. A mild positive correlation of the MS value between left bankssts and right precentral gyrus and the Hamilton Anxiety Rating Scale scores (uncorrected p = 0.041) was found in PTSD. Conclusions Our study provides the first evidence for common and distinct brain MSN abnormalities underlying the pathophysiology of GAD, PTSD, and SAD, which may aid in differential diagnosis and determining potential disorder-specific intervention targets.https://doi.org/10.1186/s12888-024-06460-1Generalized anxiety disorderMorphometric similarity networkPosttraumatic stress disorderSocial anxiety disorder |
| spellingShingle | Guifeng Tan Minlan Yuan Lun Li Hongru Zhu Su Lui Changjian Qiu Wei Zhang Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder BMC Psychiatry Generalized anxiety disorder Morphometric similarity network Posttraumatic stress disorder Social anxiety disorder |
| title | Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder |
| title_full | Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder |
| title_fullStr | Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder |
| title_full_unstemmed | Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder |
| title_short | Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder |
| title_sort | shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder posttraumatic stress disorder and social anxiety disorder |
| topic | Generalized anxiety disorder Morphometric similarity network Posttraumatic stress disorder Social anxiety disorder |
| url | https://doi.org/10.1186/s12888-024-06460-1 |
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