Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis

Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis

Metarrestin (ML246) is a first-in-class pyrrole–pyrimidine-derived small molecule that selectively targets the perinucleolar compartment (PNC). PNC is a distinct subnuclear structure predominantly found in solid tumor cells. The occurrence of PNC demonstrates a positive correlation with malignancy,...

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Bibliographic Details
Main Authors: Vivek K. Kashyap, Bhuvnesh P. Sharma, Divya Pandey, Ajay K. Singh, Godwin Peasah-Darkwah, Bhupesh Singh, Kuldeep K. Roy, Murali M. Yallapu, Subhash C. Chauhan
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
Perinucleolar compartment (PNC)
RNA polymerase III transcripts
metarrestin
cancer metastasis
eEF1A1
eEF1A2
Online Access:https://www.mdpi.com/2073-4409/13/24/2053
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