Sepsis restructures the mitochondrial calcium uniporter complex in the lymphoid tissues of mice and humans
Abstract Survivors of sepsis suffer from an elevated risk of premature death that is not explained by a higher burden of chronic diseases prior to the infection. Nearly 1 out of 4 survivors have persistent elevations of inflammation biomarkers, such as interleukin (IL) 6. These observations suggest...
Saved in:
| Main Authors: | Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R. Killinger, Andrew C. Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J. Scott, Janet S. Lee, Matthew R. Rosengart |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08475-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α
by: Anna Tosatto, et al.
Published: (2016-04-01) -
MICU dimers display unique interactomes and decode calcium signaling to regulate mitochondrial metabolism and energetics independent of the mitochondrial calcium uniporter
by: Henry Cohen, et al.
Published: (2025-06-01) -
Mitochondrial calcium uniporter is required for thermogenic adaptation mediated by reactive oxygen species signaling
by: Suji Kim, et al.
Published: (2025-07-01) -
Ablation of Mitochondrial Calcium Uniporter Alleviated Pathophenotype in a Mouse Model of Diabetic Cardiomyopathy by Inhibition of ROS Production
by: Valeria Gomez, et al.
Published: (2025-05-01) -
Mitochondrial calcium uniporter promotes MSU crystal-induced inflammation through inducing mitochondrial Ca2+ overload and ubiquitination of SIRT5 protein
by: Qingqing Yu, et al.
Published: (2025-08-01)