MiR-3664-3p through suppressing ABCG2, CYP3A4, MCL1, and MLH1 increases the sensitivity of colorectal cancer cells to irinotecan

MiR-3664-3p through suppressing ABCG2, CYP3A4, MCL1, and MLH1 increases the sensitivity of colorectal cancer cells to irinotecan

Background: Colorectal cancer (CRC) is the third most frequently diagnosed malignancy worldwide. Currently, irinotecan (CPT-11) is used alone or in combination with other drugs to treat patients with advanced CRC. However, the 5-year survival rate for metastatic CRC remains below 10 %, largely due t...

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Bibliographic Details
Main Authors: Elham Farrokhnazar, Sahar Moghbelinejad, Reza Najafipour, Ladan Teimoori-Toolabi
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Colorectal Neoplasm
Drug Resistance
Irinotecan
ATP Binding Cassette Transporter
Subfamily G, Member 2
Cytochrome P-450 CYP3A4
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025003135
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