Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study

Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study

The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has emerged as a promising therapeutic approach for the management of neurological disorders such as Lewy body dementia and...

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Main Authors: Ysaías J. Alvarado, Lenin González-Paz, José L. Paz, Marcos A. Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobos
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biology
Subjects:
Alzheimer’s disease
structural flexibility
AChE inhibitors
Online Access:https://www.mdpi.com/2079-7737/13/12/1065
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