A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats
<b>Aim:</b> This study was conducted to determine the effects of CoQ10 supplementation on some liver enzymes in diabetes status.<p> <b>Materials and Methods:</b> In the study, 38 healthy male Wistar Albino rats were used. The rats were divided into five groups. The anim...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1174 |
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| _version_ | 1841564655023030272 |
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| author | Ercan Keskin Deniz Uluışık |
| author_facet | Ercan Keskin Deniz Uluışık |
| author_sort | Ercan Keskin |
| collection | DOAJ |
| description | <b>Aim:</b> This study was conducted to determine the effects of CoQ10
supplementation on some liver enzymes in diabetes status.<p>
<b>Materials and Methods:</b> In the study, 38 healthy male Wistar Albino
rats were used. The rats were divided into five groups. The animals
in group 1, group 2 and group 3 were received standard diet, standard
diet plus IP 0,3 ml corn oil and standard diet plus IP 10 mg/kg
CoQ10 for four weeks, respectively. In group 4, diabetes was performed
via SC injections of Streptozotocin (STZ) at dose of 40 mg/kg in
0.1 M citrate buffer (pH 4.5) single daily dose for two days. In group
5, diabetes was made via SC injections of STZ at a dose of 40 mg/kg
in 0.1 M citrate buffer (pH 4.5) single daily dose for two days and
then received IP 10 mg/kg CoQ10 for four weeks. At the end of the
fourth week, blood samples were taken from all animals. In plasma
samples, aspartate aminotransferase (AST), alanine aminotransferase
(ALT), alkaline phosphatase (ALP) and γ-glutamyl transpeptidase
(GGT) levels were determined.<p>
<b>Results:</b> In diabetic rats, RBC, hemoglobin and hematocrit values
were determined to be lower (p<0.05) than the control group. CoQ10
application to diabetic animals increased (p<0.05) hematocrit value
compared diabetic group. Experimentally induced diabetes caused
significantly (p<0.05) increments in WBC count and neutrophil percentage,
while lymphocyte percentage was decreased (p<0.05) compared
to control group. CoQ10 treatment to the diabetic group markedly
(p<0.05) decreased the neutrophil percentage and increased
the lymphocyte percentage compared to diabetic group.<p>
<b>Conclusions:</b> In conclusion, it is thought that CoQ10 supplementation
may be beneficial on liver damage resulting from hazardous
effects of diabetes. |
| format | Article |
| id | doaj-art-0437a7425c194519a756cd4778ab54c3 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-0437a7425c194519a756cd4778ab54c32025-01-02T22:36:19ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533331721751174A study on coenzyme q10, experimentally induced diabetes and liver enzymes in ratsErcan KeskinDeniz Uluışık<b>Aim:</b> This study was conducted to determine the effects of CoQ10 supplementation on some liver enzymes in diabetes status.<p> <b>Materials and Methods:</b> In the study, 38 healthy male Wistar Albino rats were used. The rats were divided into five groups. The animals in group 1, group 2 and group 3 were received standard diet, standard diet plus IP 0,3 ml corn oil and standard diet plus IP 10 mg/kg CoQ10 for four weeks, respectively. In group 4, diabetes was performed via SC injections of Streptozotocin (STZ) at dose of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) single daily dose for two days. In group 5, diabetes was made via SC injections of STZ at a dose of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) single daily dose for two days and then received IP 10 mg/kg CoQ10 for four weeks. At the end of the fourth week, blood samples were taken from all animals. In plasma samples, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (GGT) levels were determined.<p> <b>Results:</b> In diabetic rats, RBC, hemoglobin and hematocrit values were determined to be lower (p<0.05) than the control group. CoQ10 application to diabetic animals increased (p<0.05) hematocrit value compared diabetic group. Experimentally induced diabetes caused significantly (p<0.05) increments in WBC count and neutrophil percentage, while lymphocyte percentage was decreased (p<0.05) compared to control group. CoQ10 treatment to the diabetic group markedly (p<0.05) decreased the neutrophil percentage and increased the lymphocyte percentage compared to diabetic group.<p> <b>Conclusions:</b> In conclusion, it is thought that CoQ10 supplementation may be beneficial on liver damage resulting from hazardous effects of diabetes.http://eurasianjvetsci.org/pdf.php3?id=1174coenzyme q10diabetesliver enzymesrat |
| spellingShingle | Ercan Keskin Deniz Uluışık A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats Eurasian Journal of Veterinary Sciences coenzyme q10 diabetes liver enzymes rat |
| title | A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats |
| title_full | A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats |
| title_fullStr | A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats |
| title_full_unstemmed | A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats |
| title_short | A study on coenzyme q10, experimentally induced diabetes and liver enzymes in rats |
| title_sort | study on coenzyme q10 experimentally induced diabetes and liver enzymes in rats |
| topic | coenzyme q10 diabetes liver enzymes rat |
| url | http://eurasianjvetsci.org/pdf.php3?id=1174 |
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