Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment
Abstract Reversing the hypoxic microenvironment of tumors is an important method to enhance the synergistic effect of tumor treatment. In this work, we developed the nanoparticles called Ce6@HGMOF, which consists of a photosensitizer (Ce6), glucose oxidase (GOX), chemotherapy drugs (HCPT) and an iro...
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BMC
2024-11-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-02921-7 |
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| author | Yukun Chen Yuanyuan Chen Zhenzhi Wang Lian Yang Yu Zhang Zhanxia Zhang Lijun Jia |
| author_facet | Yukun Chen Yuanyuan Chen Zhenzhi Wang Lian Yang Yu Zhang Zhanxia Zhang Lijun Jia |
| author_sort | Yukun Chen |
| collection | DOAJ |
| description | Abstract Reversing the hypoxic microenvironment of tumors is an important method to enhance the synergistic effect of tumor treatment. In this work, we developed the nanoparticles called Ce6@HGMOF, which consists of a photosensitizer (Ce6), glucose oxidase (GOX), chemotherapy drugs (HCPT) and an iron-based metal-organic framework (MOF). Ce6@HGMOF can consume glucose in tumor cells through “starvation therapy”, cut off their nutrition source, and produce gluconic acid and hydrogen peroxide (H2O2). Utilizing this feature, Ce6@HGMOF can produce oxygen through catalase-like catalytic activity, thereby reversing the hypoxic microenvironment of tumors. This strategy of changing the hypoxic environment can help to slow down the growth of tumor blood vessels and improve the drug-resistant microenvironment to some extent. Meanwhile, increasing the supply of oxygen can enhance the effect of photodynamic therapy (PDT) and enhance the oxidative stress damage caused by reactive oxygen species (ROS) in tumor cells. On the other hand, cancer cells usually produce higher levels of glutathione (GSH) to adapt to high oxidative stress and protect themselves. The Ce6@HGMOF we designed can also consume GSH and induce ferroptosis of tumor cells through Fenton reaction with H2O2, while enhancing the effect of PDT. This innovative synergistic strategy, the combination of PDT/ferroptosis /starvation therapy, can complement each other and enhance each other. It has great potential as a powerful new anti-tumor paradigm in the future. |
| format | Article |
| id | doaj-art-03c641344e33467da5e16b70c2081cc7 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-03c641344e33467da5e16b70c2081cc72024-11-17T12:47:11ZengBMCJournal of Nanobiotechnology1477-31552024-11-0122111810.1186/s12951-024-02921-7Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironmentYukun Chen0Yuanyuan Chen1Zhenzhi Wang2Lian Yang3Yu Zhang4Zhanxia Zhang5Lijun Jia6Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineThe Acupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineDepartment of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese MedicineCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese MedicineAbstract Reversing the hypoxic microenvironment of tumors is an important method to enhance the synergistic effect of tumor treatment. In this work, we developed the nanoparticles called Ce6@HGMOF, which consists of a photosensitizer (Ce6), glucose oxidase (GOX), chemotherapy drugs (HCPT) and an iron-based metal-organic framework (MOF). Ce6@HGMOF can consume glucose in tumor cells through “starvation therapy”, cut off their nutrition source, and produce gluconic acid and hydrogen peroxide (H2O2). Utilizing this feature, Ce6@HGMOF can produce oxygen through catalase-like catalytic activity, thereby reversing the hypoxic microenvironment of tumors. This strategy of changing the hypoxic environment can help to slow down the growth of tumor blood vessels and improve the drug-resistant microenvironment to some extent. Meanwhile, increasing the supply of oxygen can enhance the effect of photodynamic therapy (PDT) and enhance the oxidative stress damage caused by reactive oxygen species (ROS) in tumor cells. On the other hand, cancer cells usually produce higher levels of glutathione (GSH) to adapt to high oxidative stress and protect themselves. The Ce6@HGMOF we designed can also consume GSH and induce ferroptosis of tumor cells through Fenton reaction with H2O2, while enhancing the effect of PDT. This innovative synergistic strategy, the combination of PDT/ferroptosis /starvation therapy, can complement each other and enhance each other. It has great potential as a powerful new anti-tumor paradigm in the future.https://doi.org/10.1186/s12951-024-02921-7Tumor hypoxiaSynergistic treatmentAntitumorNano-drug delivery systems |
| spellingShingle | Yukun Chen Yuanyuan Chen Zhenzhi Wang Lian Yang Yu Zhang Zhanxia Zhang Lijun Jia Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment Journal of Nanobiotechnology Tumor hypoxia Synergistic treatment Antitumor Nano-drug delivery systems |
| title | Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment |
| title_full | Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment |
| title_fullStr | Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment |
| title_full_unstemmed | Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment |
| title_short | Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment |
| title_sort | iron based mof with catalase like activity improves the synergistic therapeutic effect of pdt ferroptosis starvation therapy by reversing the tumor hypoxic microenvironment |
| topic | Tumor hypoxia Synergistic treatment Antitumor Nano-drug delivery systems |
| url | https://doi.org/10.1186/s12951-024-02921-7 |
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