Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

BackgroundRipretinib, a broad-spectrum tyrosine kinase inhibitor, has been approved for the treatment of advanced gastrointestinal stromal tumors in adult patients. Clinical studies have shown that higher in vivo exposure of ripretinib correlates with improved efficacy, highlighting the potential cl...

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Main Authors:	Jiahui Lin, Aiting Jiang, Juntao Zheng, Jingjing Wu, Hao Li, Shirong Cai, Yulong He, Xiao Chen, Guoping Zhong, Ke-Jing Tang, Xinhua Zhang, Yanzhe Xia
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Pharmacology
Subjects:	therapeutic drug monitoring (TDM) pharmacokinetics ripretinib gastrointestinal stromal tumor LC-MS/MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1506931/full
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