Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis
Gut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, the deep mechanism between the microbiota-TME interaction has not been well explored. In this study, we for the first time discovered that Lactobacillus intestinalis (L. intestin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2449111 |
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| _version_ | 1841554154460282880 |
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| author | Yong Sun Qiwen Wang Yao Jiang Jiamin He Dingjiacheng Jia Man Luo Wentao Shen Qingyi Wang Yadong Qi Yifeng Lin Ying Zhang Lan Wang Liangjing Wang Shujie Chen Lina Fan |
| author_facet | Yong Sun Qiwen Wang Yao Jiang Jiamin He Dingjiacheng Jia Man Luo Wentao Shen Qingyi Wang Yadong Qi Yifeng Lin Ying Zhang Lan Wang Liangjing Wang Shujie Chen Lina Fan |
| author_sort | Yong Sun |
| collection | DOAJ |
| description | Gut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, the deep mechanism between the microbiota-TME interaction has not been well explored. In this study, we for the first time discovered that Lactobacillus intestinalis (L. intestinalis) effectively suppressed tumor growth both in the AOM/DSS-induced CRC model and the ApcMin/+ spontaneous adenoma model. Our investigation revealed that L. intestinalis increased the infiltration of immune cells, particularly dendritic cells (DC), in the TME. Mechanically, the tumor-derived CCL5 induced by L. intestinalis recruited DC chemotaxis through the NOD1/NF-κB signaling pathway. In clinical samples and datasets, we found positive correlation between L. intestinalis, CCL5 level, and the DC-related genes. Our study provided a new strategy for microbial intervention for CRC and deepened the understanding of the interaction between tumor cells and the immune microenvironment modulated by gut microbes. |
| format | Article |
| id | doaj-art-033b34d54e8c4b778dc5975aaa7be091 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-033b34d54e8c4b778dc5975aaa7be0912025-01-08T17:14:36ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2024.2449111Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesisYong Sun0Qiwen Wang1Yao Jiang2Jiamin He3Dingjiacheng Jia4Man Luo5Wentao Shen6Qingyi Wang7Yadong Qi8Yifeng Lin9Ying Zhang10Lan Wang11Liangjing Wang12Shujie Chen13Lina Fan14Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Nutrition, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaInstitution of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaGut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, the deep mechanism between the microbiota-TME interaction has not been well explored. In this study, we for the first time discovered that Lactobacillus intestinalis (L. intestinalis) effectively suppressed tumor growth both in the AOM/DSS-induced CRC model and the ApcMin/+ spontaneous adenoma model. Our investigation revealed that L. intestinalis increased the infiltration of immune cells, particularly dendritic cells (DC), in the TME. Mechanically, the tumor-derived CCL5 induced by L. intestinalis recruited DC chemotaxis through the NOD1/NF-κB signaling pathway. In clinical samples and datasets, we found positive correlation between L. intestinalis, CCL5 level, and the DC-related genes. Our study provided a new strategy for microbial intervention for CRC and deepened the understanding of the interaction between tumor cells and the immune microenvironment modulated by gut microbes.https://www.tandfonline.com/doi/10.1080/19490976.2024.2449111Lactobacillus intestinaliscolorectal cancerdendritic cellsCCL5NF-κB |
| spellingShingle | Yong Sun Qiwen Wang Yao Jiang Jiamin He Dingjiacheng Jia Man Luo Wentao Shen Qingyi Wang Yadong Qi Yifeng Lin Ying Zhang Lan Wang Liangjing Wang Shujie Chen Lina Fan Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis Gut Microbes Lactobacillus intestinalis colorectal cancer dendritic cells CCL5 NF-κB |
| title | Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis |
| title_full | Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis |
| title_fullStr | Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis |
| title_full_unstemmed | Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis |
| title_short | Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis |
| title_sort | lactobacillus intestinalis facilitates tumor derived ccl5 to recruit dendritic cell and suppress colorectal tumorigenesis |
| topic | Lactobacillus intestinalis colorectal cancer dendritic cells CCL5 NF-κB |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2449111 |
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