Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable proteins. While most TPD strategies target intracellular proteins, limited options exist for targeting extracellular or membrane proteins. Herein, cancer specific carbonic anhy...

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Bibliographic Details
Main Authors: Dohyun Kim, Gyeongseok Yang, Chaelyeong Lim, Gaeun Park, Jaemo Lee, Youjung Sim, Ja‐Hyoung Ryu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
carbonic anhydrase IX
lysosome‐targeting chimeras
peptide amphiphile
Supramolecular assembly
targeted protein degradation
Online Access:https://doi.org/10.1002/advs.202503134
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https://doi.org/10.1002/advs.202503134

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