Rational strategies for improving the efficiency of design and discovery of nanomedicines
Abstract The rise of rational strategies in nanomedicine development, such as high-throughput methods and computer-aided techniques, has led to a shift in the design and discovery patterns of nanomedicines from a trial-and-error mode to a rational mode. This transition facilitates the enhancement of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54265-3 |
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| _version_ | 1849221046728654848 |
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| author | Xiaoting Shan Ying Cai Binyu Zhu Lingli Zhou Xujie Sun Xiaoxuan Xu Qi Yin Dangge Wang Yaping Li |
| author_facet | Xiaoting Shan Ying Cai Binyu Zhu Lingli Zhou Xujie Sun Xiaoxuan Xu Qi Yin Dangge Wang Yaping Li |
| author_sort | Xiaoting Shan |
| collection | DOAJ |
| description | Abstract The rise of rational strategies in nanomedicine development, such as high-throughput methods and computer-aided techniques, has led to a shift in the design and discovery patterns of nanomedicines from a trial-and-error mode to a rational mode. This transition facilitates the enhancement of efficiency in the preclinical discovery pipeline of nanomaterials, particularly in improving the hit rate of nanomaterials and the optimization efficiency of promising candidates. Herein, we describe a directed evolution mode of nanomedicines driven by data to accelerate the discovery of nanomaterials with high delivery efficiency. Computer-aided design strategies are introduced in detail as one of the cutting-edge directions for the development of nanomedicines. Ultimately, we look forward to expanding the tools for the rational design and discovery of nanomaterials using multidisciplinary approaches. Rational design strategies may potentially boost the delivery efficiency of next-generation nanomedicines. |
| format | Article |
| id | doaj-art-02e336d4f2ce4d82b1e080d39dfe2ee8 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-02e336d4f2ce4d82b1e080d39dfe2ee82024-11-24T12:33:39ZengNature PortfolioNature Communications2041-17232024-11-011511910.1038/s41467-024-54265-3Rational strategies for improving the efficiency of design and discovery of nanomedicinesXiaoting Shan0Ying Cai1Binyu Zhu2Lingli Zhou3Xujie Sun4Xiaoxuan Xu5Qi Yin6Dangge Wang7Yaping Li8State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesPrecision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of SciencesAbstract The rise of rational strategies in nanomedicine development, such as high-throughput methods and computer-aided techniques, has led to a shift in the design and discovery patterns of nanomedicines from a trial-and-error mode to a rational mode. This transition facilitates the enhancement of efficiency in the preclinical discovery pipeline of nanomaterials, particularly in improving the hit rate of nanomaterials and the optimization efficiency of promising candidates. Herein, we describe a directed evolution mode of nanomedicines driven by data to accelerate the discovery of nanomaterials with high delivery efficiency. Computer-aided design strategies are introduced in detail as one of the cutting-edge directions for the development of nanomedicines. Ultimately, we look forward to expanding the tools for the rational design and discovery of nanomaterials using multidisciplinary approaches. Rational design strategies may potentially boost the delivery efficiency of next-generation nanomedicines.https://doi.org/10.1038/s41467-024-54265-3 |
| spellingShingle | Xiaoting Shan Ying Cai Binyu Zhu Lingli Zhou Xujie Sun Xiaoxuan Xu Qi Yin Dangge Wang Yaping Li Rational strategies for improving the efficiency of design and discovery of nanomedicines Nature Communications |
| title | Rational strategies for improving the efficiency of design and discovery of nanomedicines |
| title_full | Rational strategies for improving the efficiency of design and discovery of nanomedicines |
| title_fullStr | Rational strategies for improving the efficiency of design and discovery of nanomedicines |
| title_full_unstemmed | Rational strategies for improving the efficiency of design and discovery of nanomedicines |
| title_short | Rational strategies for improving the efficiency of design and discovery of nanomedicines |
| title_sort | rational strategies for improving the efficiency of design and discovery of nanomedicines |
| url | https://doi.org/10.1038/s41467-024-54265-3 |
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