Distinct microbiome dysbiosis and epigenetic anomaly in esophageal adenocarcinoma and its underlying Barrett’s esophagus

Distinct microbiome dysbiosis and epigenetic anomaly in esophageal adenocarcinoma and its underlying Barrett’s esophagus

Abstract Interaction between host genotoxic changes and mucosa-associated microbiome (MAM) dysbiosis may have a role in various digestive cancers. We investigated MAM in Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) progression sequence and its association with host genotoxic changes....

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Bibliographic Details
Main Authors: Takuya Shijimaya, Tomomitsu Tahara, Jumpei Yamazaki, Sanshiro Kobayashi, Yasushi Matsumoto, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Tomoyuki Shibata, Makoto Naganuma
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Clinical Epigenetics
Subjects:
Barrett’s esophagus
Esophageal adenocarcinoma
Mucosa-associated microbiome
DNA methylation
RRBS
Telomere shortening
Online Access:https://doi.org/10.1186/s13148-024-01801-z
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