Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

Regulatory T cells (Tregs) are central to immune homeostasis and controlling inflammation through multiple mechanisms, however, recent discoveries and advances in technology reveal that Tregs exert a diverse array of functions beyond mere immunosuppression, adapting uniquely to the specialized envir...

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Bibliographic Details
Main Authors: Bat-Erdene Jugder, Eunchong Park, Lijuan Du, Chetan Jawale, Nikolay Popov, Zengli Guo, Kyle J. Bednar, Tatiana Ort
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
Tregs (regulatory T cells)
tissue Tregs
autoimmunity
immune tolerance
CAR-Treg
Treg plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1650451/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1650451/full

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