Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions

Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions

Abstract Mammals exhibit an unusual variation in their maximum lifespan potential, measured as the longest recorded longevity of any individual in a species. Evidence suggests that lifespan increases follow expansion in brain size relative to body mass. Here, we found significant gene family size ex...

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Main Authors: Huseyin Kilili, Benjamin Padilla-Morales, Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Karina Díaz-Barba, Paola Cornejo-Paramo, Orsolya Vincze, Mathieu Giraudeau, Stephen J. Bush, Zhidan Li, Lu Chen, Evangelos Mourkas, Sergio Ancona, Alejandro Gonzalez-Voyer, Diego Cortez, Humberto Gutierrez, Tamás Székely, Alín P. Acuña-Alonzo, Araxi O. Urrutia
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Longevity
Ageing
Immunity
Gene duplication
Gene expression
Gene family size
Online Access:https://doi.org/10.1038/s41598-025-98786-3
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https://doi.org/10.1038/s41598-025-98786-3

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