Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration

Coexistence of CN1A autoantibodies in GAD65 encephalitis exacerbates neurodegeneration

Abstract Background Autoantibodies targeting the intracellular 65-kDa isoform of glutamic acid decarboxylase (anti-GAD65) have been associated with a variety of autoimmune-related syndromes involving a spectrum of difficult-to-treat neurological disorders. However, the pathophysiological role of ant...

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Main Authors: Annika Breuer, Delara Kamalizade, Tobias Baumgartner, Juliane L. Berns, Thoralf Opitz, Franziska S. Thaler, Susanne Schoch, Lars Komorowski, Christoph Helmstaedter, Rainer Surges, Albert J. Becker, Julika Pitsch
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neuroinflammation
Subjects:
Glutamate decarboxylase 65 (GAD65)
Cytosolic 5'-nucleotidase 1A (CN1A)
Temporal lobe epilepsy
Limbic encephalitis
Autoimmune encephalitis
Online Access:https://doi.org/10.1186/s12974-025-03521-4
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https://doi.org/10.1186/s12974-025-03521-4

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