Pilot study of cerebrospinal fluid biomarkers reveals inflammatory changes in patients with paranoid schizophrenia

Pilot study of cerebrospinal fluid biomarkers reveals inflammatory changes in patients with paranoid schizophrenia

Abstract Paranoid schizophrenia is a severe mental illness with both positive and negative symptoms. Currently, the role of peripheral and central inflammation is increasingly suspected as possible factor in the pathogenesis of schizophrenia. This retrospective, monocentric pilot study investigated...

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Main Authors: Franz Felix Konen, Philipp Sebastian Gehring, Hannah Benedictine Maier, Sebastian Schröder, Seda Nur Türker, Helge Frieling, Stefan Bleich, André Huss, Hayrettin Tumani, Daniel Lüdecke, Jürgen Gallinat, Berend Malchow, Niels Hansen, Jens Wiltfang, Alexandra Neyazi, Thomas Skripuletz, CAP (Cerebrospinal Fluid Analysis in Psychiatry) Consortium
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Paranoid schizophrenia
Cerebrospinal fluid
Kappa free light chains
Neurofilament light chains
Cytokines
Chemokines
Online Access:https://doi.org/10.1038/s41598-025-13367-8
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https://doi.org/10.1038/s41598-025-13367-8

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