Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment

Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment

Recently, a variety of physiologically based pharmacokinetic (PBPK) models have been developed for the essential element manganese. This paper reviews the development of PBPK models (e.g., adult, pregnant, lactating, and neonatal rats, nonhuman primates, and adult, pregnant, lactating, and neonatal...

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Bibliographic Details
Main Authors:	Michael D. Taylor, Harvey J. Clewell, Melvin E. Andersen, Jeffry D. Schroeter, Miyoung Yoon, Athena M. Keene, David C. Dorman
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Series:	Journal of Toxicology
Online Access:	http://dx.doi.org/10.1155/2012/791431
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