Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer

Abstract Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cells to sustain survival signals. In this report, we describe a novel oncogenic signaling pathway exclusively acting in mutated epidermal growth factor receptor (EGFR) non‐small cell lung cancer (N...

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Main Authors: Azhar Ali, Elena Levantini, Jun Ting Teo, Julian Goggi, John G Clohessy, Chan Shuo Wu, Leilei Chen, Henry Yang, Indira Krishnan, Olivier Kocher, Junyan Zhang, Ross A Soo, Kishore Bhakoo, Tan Min Chin, Daniel G Tenen
Format: Article
Language:English
Published: Springer Nature 2018-02-01
Series:EMBO Molecular Medicine
Subjects:
acquired resistance
EGFR‐TKI
FASN
NSCLC
palmitoylation
Online Access:https://doi.org/10.15252/emmm.201708313
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https://doi.org/10.15252/emmm.201708313

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