Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)

Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)

IntroductionMultidrug resistance (MDR) in cancer therapy, frequently driven by overexpression of ATP-binding cassette (ABC) transporters—particularly ABCG2—continues to undermine the efficacy of chemotherapeutic regimens. Tinodasertib (ETC-206), a selective ATP-competitive MNK1/2 kinase inhibitor, c...

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Bibliographic Details
Main Authors: Haigan Yang, Zheshen Li, Zhuoxun Wu, Xiang Chen, Letao Bo, Harsh Patel, Bohan Zhang, Wenjun Xiong, Wei Wang, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
ATP-binding cassette (ABC) transporter
tinodasertib
ETC-206
ABCG2
multidrug resistance (MDR)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1606857/full
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