Establishment and evaluation of a patient-derived organoids-based xenograft model of primary aldosteronism using [18F]AlF-NOTA-pentixather PET/CT: bridging preclinical and clinical imaging

Establishment and evaluation of a patient-derived organoids-based xenograft model of primary aldosteronism using [18F]AlF-NOTA-pentixather PET/CT: bridging preclinical and clinical imaging

Abstract Background Primary aldosteronism (PA) is a leading cause of secondary hypertension, but the lack of representative preclinical models hampers translational research and imaging evaluation. We aimed to establish a patient-derived organoids-based xenograft (PDOX) model of PA and to assess its...

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Main Authors: Xuezhou Zhang, Tiantian Mou, Yuxuan Wang, Qi Miao, Wei Wang, Zhipeng Sun, Yuxuan Bo, Jiayuan Cui, Jiahui Zhao, Mingchuan Li, Baoan Hong, Hongzhi Mi, Ning Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Primary aldosteronism
Organoids
PDOX model
[18F]AlF-NOTA-pentixather PET/CT
Online Access:https://doi.org/10.1186/s12967-025-06979-1
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