Short‐Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial

Short‐Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial

ABSTRACT Background Drug resistance poses a formidable challenge in managing acute manic episodes in bipolar I disorder, leading to suboptimal treatment outcomes. This study investigates the efficacy of folate and vitamin B6 supplementation as an adjunct to sodium valproate in improving treatment re...

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Bibliographic Details
Main Authors: Farzad Akbarzadeh, Andisheh Talaei, Mohsen Nematy, Dina Ganji, Alireza Ebrahimi, Ali Talaei
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Brain and Behavior
Subjects:
bipolar I disorder
folate
mania
sodium valproate
vitamin B6
Online Access:https://doi.org/10.1002/brb3.70432
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https://doi.org/10.1002/brb3.70432

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