Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET
Abstract This study investigated the relationship between dyslipidemia prior to conception and the risk of preeclampsia (PE) in women pregnant by in vitro fertilization and embryo transfer (IVF-ET). The retrospective cohort study consisted of 2994 women who conceived by IVF-ET and delivered live neo...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-03513-7 |
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| author | Shaomin Chen Yang Wang Zhaoyu Wang Liyuan Tao Yongqing Wang Yuan Wei Zhaoping Li Rong Li |
| author_facet | Shaomin Chen Yang Wang Zhaoyu Wang Liyuan Tao Yongqing Wang Yuan Wei Zhaoping Li Rong Li |
| author_sort | Shaomin Chen |
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| description | Abstract This study investigated the relationship between dyslipidemia prior to conception and the risk of preeclampsia (PE) in women pregnant by in vitro fertilization and embryo transfer (IVF-ET). The retrospective cohort study consisted of 2994 women who conceived by IVF-ET and delivered live neonates. The study population was divided into two components: a training set for the prediction model development (2288 women) and a test set for validation (706 women). Multivariable logistic regression was used for the development and validation of predictive model for the risk of PE. Among the 2288 women in the training set, 266 women (11.6%) developed PE. Multiple logistic regression analysis identified independent predictors for PE: triglyceride (TG) [adjusted odds ratio (aOR) 1.284; 95% confidence interval (CI) 1.113–1.489, P < 0.001]; pre-pregnancy BMI; pre- chronic hypertension; twin pregnancy; embryo transfer protocol. These independent predictors for PE were used to form a risk prediction model, and the area under the receiver-operator characteristic (ROC) curve (AUC) in the training and the test set was 0.77 (95% CI 0.73–0.80)and 0.71 AUC (95% CI 0.65–0.77), respectively. In conclusion, higher TG levels before pregnancy were independently associated with the risk for PE in women pregnant by IVF-ET. |
| format | Article |
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| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-00d86563d14d4a34b46b3669a56b66dd2025-08-20T02:03:31ZengNature PortfolioScientific Reports2045-23222025-05-011511910.1038/s41598-025-03513-7Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ETShaomin Chen0Yang Wang1Zhaoyu Wang2Liyuan Tao3Yongqing Wang4Yuan Wei5Zhaoping Li6Rong Li7Department of Cardiology, Institute of Vascular Medicine, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Ministry of Health, Ministry of EducationCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Peking University Third Hospital), Ministry of EducationResearch Center of Clinical Epidemiology, Peking University Third HospitalResearch Center of Clinical Epidemiology, Peking University Third HospitalDepartment of Obstetrics and Gynecology, Peking University Third HospitalDepartment of Obstetrics and Gynecology, Peking University Third HospitalDepartment of Cardiology, Institute of Vascular Medicine, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Ministry of Health, Ministry of EducationCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Key Laboratory of Assisted Reproduction (Peking University), Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Peking University Third Hospital), Ministry of EducationAbstract This study investigated the relationship between dyslipidemia prior to conception and the risk of preeclampsia (PE) in women pregnant by in vitro fertilization and embryo transfer (IVF-ET). The retrospective cohort study consisted of 2994 women who conceived by IVF-ET and delivered live neonates. The study population was divided into two components: a training set for the prediction model development (2288 women) and a test set for validation (706 women). Multivariable logistic regression was used for the development and validation of predictive model for the risk of PE. Among the 2288 women in the training set, 266 women (11.6%) developed PE. Multiple logistic regression analysis identified independent predictors for PE: triglyceride (TG) [adjusted odds ratio (aOR) 1.284; 95% confidence interval (CI) 1.113–1.489, P < 0.001]; pre-pregnancy BMI; pre- chronic hypertension; twin pregnancy; embryo transfer protocol. These independent predictors for PE were used to form a risk prediction model, and the area under the receiver-operator characteristic (ROC) curve (AUC) in the training and the test set was 0.77 (95% CI 0.73–0.80)and 0.71 AUC (95% CI 0.65–0.77), respectively. In conclusion, higher TG levels before pregnancy were independently associated with the risk for PE in women pregnant by IVF-ET.https://doi.org/10.1038/s41598-025-03513-7In vitro fertilization and embryo transferPreeclampsiaDyslipidemiaPrediction model |
| spellingShingle | Shaomin Chen Yang Wang Zhaoyu Wang Liyuan Tao Yongqing Wang Yuan Wei Zhaoping Li Rong Li Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET Scientific Reports In vitro fertilization and embryo transfer Preeclampsia Dyslipidemia Prediction model |
| title | Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET |
| title_full | Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET |
| title_fullStr | Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET |
| title_full_unstemmed | Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET |
| title_short | Pre conception dyslipidemia and risk for preeclampsia in women undergoing IVF ET |
| title_sort | pre conception dyslipidemia and risk for preeclampsia in women undergoing ivf et |
| topic | In vitro fertilization and embryo transfer Preeclampsia Dyslipidemia Prediction model |
| url | https://doi.org/10.1038/s41598-025-03513-7 |
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