Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study
ObjectiveTo investigate changes of brain functional activity in patients with acute unilateral vestibulopathy (AUVP) using functional magnetic resonance imaging (fMRI).MethodsWe studied 32 AUVP patients and 30 healthy controls (HC) who received resting-state fMRI scanning. Methods of voxel-based amp...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1515262/full |
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| author | Zhengwei Chen Liangqun Rong Lijie Xiao Jie Rao Haiyan Liu Tengfei Liu Fei Chen Jun Zhang Lu Wang Xi Li Xiue Wei |
| author_facet | Zhengwei Chen Liangqun Rong Lijie Xiao Jie Rao Haiyan Liu Tengfei Liu Fei Chen Jun Zhang Lu Wang Xi Li Xiue Wei |
| author_sort | Zhengwei Chen |
| collection | DOAJ |
| description | ObjectiveTo investigate changes of brain functional activity in patients with acute unilateral vestibulopathy (AUVP) using functional magnetic resonance imaging (fMRI).MethodsWe studied 32 AUVP patients and 30 healthy controls (HC) who received resting-state fMRI scanning. Methods of voxel-based amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were adopted to compare the difference in brain function between the two groups. In addition, we evaluated the associations between abnormal neuroimaging results and clinical data in AUVP patients.ResultsCompared with HC, patients with AUVP showed lower ALFF in brain regions of bilateral insular, right precentral gyrus, left inferior frontal gyrus and right middle frontal gyrus, as well as higher ALFF in left cerebellar anterior lobe. Using these abnormal brain areas as seeds, we observed decreased FC between left insular and left precuneus in AUVP patients. Furthermore, AUVP patients showed increased FC between left insular and left supplementary motor area. Results of correlation analysis indicated that ALFF value (z-value) in left insular was negatively correlated with the canal paresis value (p = 0.005, r = −0.483), and the FC (z-value) between left insular and left precuneus was negatively correlated with dizziness handicap inventory score (p = 0.012, r = −0.438) in patients with AUVP.ConclusionPatients with AUVP during acute period showed altered functional activity and connectivity in brain regions mainly involved in motor control and vestibular information processing. These changes in brain functional activity and connectivity were potentially attributed to decreased vestibular input resulting from unilateral peripheral vestibular impairment. |
| format | Article |
| id | doaj-art-00d66a61a20a47009a6bf3f24ed5e8f1 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-00d66a61a20a47009a6bf3f24ed5e8f12025-01-13T05:10:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.15152621515262Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI studyZhengwei Chen0Liangqun Rong1Lijie Xiao2Jie Rao3Haiyan Liu4Tengfei Liu5Fei Chen6Jun Zhang7Lu Wang8Xi Li9Xiue Wei10Department of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Lishui Central Hospital, Lishui, Zhejiang, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaNeurology Department, Third Affiliated Hospital of Shanghai University, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People’s Hospital, Wenzhou, Zhejiang, ChinaDepartment of Neurology, Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaObjectiveTo investigate changes of brain functional activity in patients with acute unilateral vestibulopathy (AUVP) using functional magnetic resonance imaging (fMRI).MethodsWe studied 32 AUVP patients and 30 healthy controls (HC) who received resting-state fMRI scanning. Methods of voxel-based amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were adopted to compare the difference in brain function between the two groups. In addition, we evaluated the associations between abnormal neuroimaging results and clinical data in AUVP patients.ResultsCompared with HC, patients with AUVP showed lower ALFF in brain regions of bilateral insular, right precentral gyrus, left inferior frontal gyrus and right middle frontal gyrus, as well as higher ALFF in left cerebellar anterior lobe. Using these abnormal brain areas as seeds, we observed decreased FC between left insular and left precuneus in AUVP patients. Furthermore, AUVP patients showed increased FC between left insular and left supplementary motor area. Results of correlation analysis indicated that ALFF value (z-value) in left insular was negatively correlated with the canal paresis value (p = 0.005, r = −0.483), and the FC (z-value) between left insular and left precuneus was negatively correlated with dizziness handicap inventory score (p = 0.012, r = −0.438) in patients with AUVP.ConclusionPatients with AUVP during acute period showed altered functional activity and connectivity in brain regions mainly involved in motor control and vestibular information processing. These changes in brain functional activity and connectivity were potentially attributed to decreased vestibular input resulting from unilateral peripheral vestibular impairment.https://www.frontiersin.org/articles/10.3389/fneur.2024.1515262/fullacute unilateral vestibulopathyvestibular neuritisfMRIamplitude of low-frequency fluctuationfunctional connectivity |
| spellingShingle | Zhengwei Chen Liangqun Rong Lijie Xiao Jie Rao Haiyan Liu Tengfei Liu Fei Chen Jun Zhang Lu Wang Xi Li Xiue Wei Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study Frontiers in Neurology acute unilateral vestibulopathy vestibular neuritis fMRI amplitude of low-frequency fluctuation functional connectivity |
| title | Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study |
| title_full | Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study |
| title_fullStr | Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study |
| title_full_unstemmed | Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study |
| title_short | Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study |
| title_sort | altered amplitude of low frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy a resting state fmri study |
| topic | acute unilateral vestibulopathy vestibular neuritis fMRI amplitude of low-frequency fluctuation functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1515262/full |
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